Target Organs: p97 inhibitor TargetMol T1853.

Soluble to 100 mM in DMSO Tocris Bioscience 6180

Experimental Solubility: DMSO 40 mg/mL Water 40 mg/mL MedChem Express HY-15713.

Experimental LogP: 4.578 LabNetwork (old) LN01301668.

Experimental Boiling Point: 769.3 ☌ Cayman Chemical (old) CM172525.

Experimental Physico-chemical Properties.

Our findings indicate that porous Zn-MOFs play a significant role in the development of a TFN membrane with high desalination performance and chlorine resistance. Therefore, the developed TFN membrane has potential to solve trade-off difficulties between permeability and selectivity. Furthermore, the membranes showed outstanding water stability throughout 72 h filtration and chlorine resistance after a 264 h chlorine-soaking test because of the better compatibility between the polyamide and Zn-MOF nanofiller. Moreover, the highest-performing membrane (50 mg/L Zn-MOF added nanofiller) not only exhibited a water permeability of 2.46 ± 0.12 LMH/bar but also maintained selectivity to reject NaCl (>90%) and Na 2SO 4 (>95%), similar to benchmark values. The results indicate that all four studied TFN membranes with incorporated Zn-MOFs enhanced the water permeability while retaining high salt rejection compared to a thin-film composite membrane. The characterization results revealed that Zn-MOFs strongly bind with polyamide and significantly change the membrane chemistry and morphology.

The presence and layout of Zn-MOFs on the top layer of the membranes were confirmed by X-ray photoelectron spectroscopy, scanning electron microscopy, and ζ potential analysis. The actual effects of varying the amount of Zn-MOF added as a nanofiller on the physicochemical properties and desalination performance of TFN membranes are studied. In this work, we investigate the incorporation of porous zinc-based MOFs (Zn-MOFs) into a polyamide active layer for the fabrication of TFN membranes on porous poly(phenylsulfone) (PPSU) support layers through an interfacial polymerization approach. However, the relationship between the unique physicochemical properties and performance of engineered MOF-based membranes has yet to be extensively investigated.

Metal–organic framework (MOF) materials have received extensive attention for the design of advanced thin-film nanocomposite (TFN) membranes with excellent permselectivity.

Nms chlorine